Melanotan-II/MT2

Melanotan II, alpha-Melanocyte stimulating hormone, Melanotan peptid, or MSH is a synthetic variant of a natural peptide hormone that’s responsible for melanogenesis (a process that cause pigmentation of the skin) in the body.

The synthetically produced and injectable peptide hormone is commonly used for improved sexual stamina and to darken skin pigment. The drug is among the legal peptides for sale, sold in powdered form which is later reconstituted for subcutaneous injections.

Melanotan II was initially developed in the 1990s at the University of Arizona. Led by a popular dermatologist Norman Levine, the research team which was behind the invention of the drug used frogs for experimenting the effectiveness and safety of a hormone known as Alpha MSH before using it on people. The hormone caused the darkening of the pigments of the frogs used in the experiment.

Upon confirming the effectiveness of Alpha MSH in darkening frog skin pigments, they modified Melanotan II peptide in a way that would be friendly to the human body and put it through clinical trials. During the tests, one of the people who had taken the drug reported to Levine that he was experiencing spontaneous erections as a result of it.

Following such reports, the research team also achieved another success as far as discovering Melanotan-II benefits is concerned by discovering Bremelanotide (PT-141)  , an erectile dysfunction-focused derivative of the drug. Both Melanotan II peptide and Bremelanotide were patented and licensed for sale to and use by biotechnology companies for possible development into valuable prescription drugs.

Melanotan II works by activating some melanocortin receptors, leading to improved skin tanning, increased sexual libido, better lipid metabolism and suppressed appetite.  In a study that was done to investigate the influence of Melanotan 2 on food intake, it was noted that the peptide hormone activated the central melanocortin (MC) when fed induced and fed to mice.

The mice which were used in the experiment had reduced body weight and viscera adipose tissue following the six-day treatment with Melanotan peptide. Also, the substance led to the suppression of the mice’s caloric intake.

The findings are a clear indication that Melanotan peptide can help people who want to shed off some weight, especially the obese and the overweight, to minimize their carbohydrate and calorie intake.

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